Description

3-Difluoromethoxy-4-Methyl-Benzeneboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly in the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex biaryl motifs for therapeutic applications.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific aromatic frameworks.
• Material Science Research: Serves as a monomer or building block for creating novel organic electronic materials, such as those used in OLEDs or organic semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tools for studying biological systems and drug discovery.
• Custom Synthesis and Contract Manufacturing: A key reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	3-Difluoromethoxy-4-Methyl-Benzeneboronic Acid
CAS No.	958451-74-6
Molecular Formula	C8H9BF2O3
Molecular Weight	201.97 g/mol
Synonyms	(3-(Difluoromethoxy)-4-methylphenyl)boronic acid; 4-Methyl-3-(difluoromethoxy)benzeneboronic acid; 3-(Difluoromethoxy)-4-methylbenzeneboronic acid; Boronic acid, B-[3-(difluoromethoxy)-4-methylphenyl]-; 958451-74-6; 3-Difluoromethoxy-4-methylphenylboronic acid
EINECS	Contact for details

Quality Control

Our 3-Difluoromethoxy-4-Methyl-Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.