Description

2-Difluoromethoxy-4-Fluoro-Benzeneboronic Acid is a high-purity, synthetically valuable organoboron building block essential for modern cross-coupling reactions. Its molecular structure, featuring both difluoromethoxy and fluoro substituents, makes it a critical intermediate for introducing specific fluorinated motifs into target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex, fluorinated biaryl structures found in drug candidates.
• Agrochemical Research: Used to construct novel herbicide and pesticide molecules where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Material Science: Serves as a building block for creating fluorinated organic frameworks, liquid crystals, and polymers with tailored electronic properties.
• Chemical Synthesis: Employed in medicinal chemistry for the late-stage functionalization and diversification of compound libraries during lead optimization.
• Diagnostic Reagents: Potential use in synthesizing fluorinated probes and tags for imaging and biochemical assays.

Basic Information

Product Name	2-Difluoromethoxy-4-Fluoro-Benzeneboronic Acid
CAS No.	958451-73-5
Molecular Formula	C7H6BF3O3
Molecular Weight	213.93 g/mol
Synonyms	(2-(Difluoromethoxy)-4-fluorophenyl)boronic Acid; 4-Fluoro-2-(difluoromethoxy)benzeneboronic Acid; 2-(Difluoromethoxy)-4-fluorobenzeneboronic Acid; 958451-73-5; Boronic acid, B-[2-(difluoromethoxy)-4-fluorophenyl]-; B-[2-(Difluoromethoxy)-4-fluorophenyl]boronic Acid
EINECS	Contact for details

Quality Control

Our 2-Difluoromethoxy-4-Fluoro-Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee reproducible performance in sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.