Description

4-Difluoromethoxy-3-Methyl-Benzeneboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a key intermediate in cross-coupling reactions, enabling the precise construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the difluoromethoxy group for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for creating functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the development of chemical probes and inhibitors that target specific enzymes or biological pathways.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel boron-containing catalysts and ligands used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring high-fidelity boronic acid reagents.

Basic Information

Product Name	4-Difluoromethoxy-3-Methyl-Benzeneboronic Acid
CAS No.	958451-72-4
Molecular Formula	C8H9BF2O3
Molecular Weight	201.97 g/mol
Synonyms	(4-(Difluoromethoxy)-3-methylphenyl)boronic acid; 3-Methyl-4-(difluoromethoxy)benzeneboronic acid; 4-(Difluoromethoxy)-3-methylbenzeneboronic acid; Boronic acid, B-[4-(difluoromethoxy)-3-methylphenyl]-; 958451-72-4; Benzeneboronic acid, 4-(difluoromethoxy)-3-methyl-
EINECS	Contact for details

Quality Control

Every batch of 4-Difluoromethoxy-3-Methyl-Benzeneboronic Acid is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and elemental analysis, is performed to guarantee identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.