Description

1-Difluoromethoxy-4-Fluoro-Benzeneboronic Acid is a high-purity, functionalized benzeneboronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly in the development of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key synthon for constructing fluorinated and difluoromethoxy-containing drug candidates, including kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides with improved metabolic stability and activity.
• Material Science: Building block for synthesizing functionalized organic frameworks, liquid crystals, and electronic materials.
• Suzuki-Miyaura Cross-Coupling: A versatile reagent for palladium-catalyzed coupling reactions to create biaryl and heterobiaryl structures.
• Chemical Research & Development: Enables medicinal chemistry exploration and structure-activity relationship (SAR) studies in academic and industrial R&D labs.
• Fluorine Chemistry: Serves as a valuable substrate for introducing fluorine and difluoromethoxy groups into target molecules.

Basic Information

Product Name	1-Difluoromethoxy-4-Fluoro-Benzeneboronic Acid
CAS No.	958451-71-3
Molecular Formula	C7H6BF3O3
Molecular Weight	201.93 g/mol
Synonyms	4-Fluoro-1-(difluoromethoxy)benzeneboronic Acid; (4-Fluoro-2-(difluoromethoxy)phenyl)boronic Acid; 4-Fluoro-2-(difluoromethoxy)phenylboronic Acid; 2-(Difluoromethoxy)-4-fluorophenylboronic Acid; 958451-71-3; Benzeneboronic acid, 1-(difluoromethoxy)-4-fluoro-; 1-Difluoromethoxy-4-fluorobenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 1-Difluoromethoxy-4-Fluoro-Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under GMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.