Description

3-Difluoromethoxy-4-Fluoro-Benzeneboronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is valued for its role in facilitating key cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the creation of novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, which are prevalent in many drug candidates.
• Pharmaceutical Intermediate: Used in the research and development of new active pharmaceutical ingredients (APIs), particularly those containing difluoromethoxy and fluoro substituents for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Utilized in the synthesis of organic electronic materials, such as those for OLEDs or semiconductors, where precise fluorination patterns are critical.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific fluorinated aromatic structures.

Basic Information

Product Name	3-Difluoromethoxy-4-Fluoro-Benzeneboronic Acid
CAS No.	958451-70-2
Molecular Formula	C7H6BF3O3
Molecular Weight	201.93 g/mol
Synonyms	4-Fluoro-3-(difluoromethoxy)benzeneboronic Acid; (4-Fluoro-3-(difluoromethoxy)phenyl)boronic Acid; 3-(Difluoromethoxy)-4-fluorobenzeneboronic Acid; 958451-70-2; Boronic acid, B-[4-fluoro-3-(difluoromethoxy)phenyl]-; B-[4-Fluoro-3-(difluoromethoxy)phenyl]boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 3-Difluoromethoxy-4-Fluoro-Benzeneboronic Acid is produced and tested under strict quality management protocols to ensure consistency and high purity for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.