Description

4-Difluoromethoxy-3-Fluoro-Benzeneboronic Acid is a high-purity, multi-fluorinated boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Employed in the development of organic electronic materials, including OLEDs and semiconductors, due to its fluorine-substituted aromatic structure.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Difluoromethoxy-3-Fluoro-Benzeneboronic Acid
CAS No.	958451-69-9
Molecular Formula	C7H6BF3O3
Molecular Weight	205.93 g/mol
Synonyms	3-Fluoro-4-(difluoromethoxy)benzeneboronic Acid; (3-Fluoro-4-(difluoromethoxy)phenyl)boronic Acid; 4-(Difluoromethoxy)-3-fluorobenzeneboronic Acid; 958451-69-9; B-(3-Fluoro-4-(difluoromethoxy)phenyl)boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Difluoromethoxy-3-Fluoro-Benzeneboronic Acid is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical applications. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.