Description

(R,S)-Naproxen-1,3,4,5,7,8-D6 is a deuterium-labeled isotopologue of the non-steroidal anti-inflammatory drug (NSAID) naproxen, with the CAS registry number 958293-99-7. This compound is an essential internal standard and reference material for quantitative bioanalytical studies, enabling precise and accurate measurement of naproxen levels in complex biological matrices. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetics, metabolism, and bioequivalence research.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the accurate quantification of naproxen in plasma, serum, and urine samples using mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a stable isotope-labeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of naproxen.
• Bioanalytical Method Development and Validation: Serves as a key component in developing robust, regulatory-compliant (FDA, EMA) analytical methods.
• Clinical and Pre-clinical Research: Enables precise monitoring of drug concentration in therapeutic drug monitoring and toxicology studies.
• Pharmaceutical Quality Control: Can be utilized in impurity profiling and stability-indicating assay methods for naproxen formulations.
• Isotope Dilution Mass Spectrometry (IDMS): Provides the highest level of accuracy for definitive methods in reference laboratories.

Basic Information

Product Name	(R,S)-Naproxen-1,3,4,5,7,8-D6
CAS No.	958293-99-7
Molecular Formula	C₁₄H₁₀D₆O₃
Molecular Weight	236.31 g/mol
Synonyms	Naproxen-d6; (+/-)-Naproxen-d6; DL-Naproxen-d6; 2-(6-Methoxy-2-naphthyl-d6)propionic Acid; (RS)-Naproxen-1,3,4,5,7,8-D6; 6-Methoxy-α-methyl-2-naphthaleneacetic-1,3,4,5,7,8-d6 Acid; Aleve-d6 (labeled analog); Anaprox-d6 (labeled analog)
EINECS	Contact for details

Quality Control

Our deuterated standards are produced under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch of (R,S)-Naproxen-1,3,4,5,7,8-D6 is characterized by NMR (¹H, ¹³C) and high-resolution mass spectrometry (HRMS) to confirm structure and isotopic enrichment. We provide comprehensive Certificates of Analysis (COA) detailing chemical purity (by HPLC), isotopic purity (by MS), and specific analytical data, supporting compliance with GLP and ISO 17025 standards for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive and should be stored away from light. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.