Description

(R)-(-)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2.2]-Paracyclophane is a highly specialized chiral phosphine ligand belonging to the paracyclophane family. This compound matters for its exceptional ability to induce stereoselectivity in transition metal-catalyzed reactions, a critical factor in synthesizing enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over molecular chirality.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the production of enantiopure pharmaceutical intermediates.
• Catalyst component in asymmetric C-C bond-forming reactions, such as cross-couplings and additions.
• Key reagent in the synthesis of chiral active pharmaceutical ingredients (APIs) and natural products.
• Research tool for developing novel homogeneous catalysts in academic and industrial laboratories.
• Use in the preparation of optically pure agrochemicals and flavors/fragrances.
• Potential applications in materials science for creating chiral polymers or surfaces.

Basic Information

Product Name	(R)-(-)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2.2]-Paracyclophane
CAS No.	957782-11-5
Molecular Formula	C52H48P2
Molecular Weight	734.89 g/mol
Synonyms	(R)-(-)-4,12-Bis[bis(3,5-dimethylphenyl)phosphino][2.2]paracyclophane; (R)-PhanePhos Derivative; (R)-4,12-Bis(di-3,5-xylylphosphino)[2.2]paracyclophane; (R)-(-)-4,12-Bis(di-3,5-dimethylphenylphosphino)[2.2]paracyclophane; (R)-XYL-PhanePhos; (R)-(-)-4,12-Bis[bis(3,5-dimethylphenyl)phosphino]-[2.2]-paracyclophane; (R)-(-)-4,12-Bis(di-3,5-xylylphosphino)[2.2]paracyclophane; Chiral Paracyclophane Phosphine Ligand
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of (R)-(-)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2.2]-Paracyclophane is characterized by advanced analytical techniques to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.