Description

(4S,5R)-3-(Fmoc-Ile)-2,2,5-Trimethyl-Oxazolidine-4-Carboxylic Acid is a high-purity, chiral oxazolidine derivative specifically designed for advanced peptide synthesis. This compound serves as a critical building block, offering superior stereochemical control and protection for isoleucine residues during solid-phase and solution-phase peptide assembly. It is an essential reagent for research and development laboratories in the pharmaceutical and biotechnology sectors, enabling the production of complex therapeutic peptides, peptidomimetics, and other bioactive molecules with precise structural integrity.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid derivative for the controlled, sequential addition of isoleucine in Fmoc-based synthesis protocols.
• Solution-Phase Peptide Synthesis: Used in the preparation of peptide fragments and conjugates where solution-phase methodologies are preferred.
• Pharmaceutical Research & Development: A key intermediate in the discovery and development of novel peptide-based drugs, hormones, and diagnostic agents.
• Peptidomimetic Design: Employed to create stable, non-natural peptide analogs with enhanced pharmacological properties.
• Combinatorial Chemistry Libraries: Utilized for generating diverse libraries of peptide compounds for high-throughput screening against biological targets.
• Academic & Institutional Research: Supports fundamental studies in organic chemistry, medicinal chemistry, and biochemistry focused on peptide structure and function.

Basic Information

Product Name	(4S,5R)-3-(Fmoc-Ile)-2,2,5-Trimethyl-Oxazolidine-4-Carboxylic Acid
CAS No.	957780-52-8
Molecular Formula	C28H33NO6
Molecular Weight	479.57 g/mol
Synonyms	Fmoc-Ile-Oxazolidine; (4S,5R)-3-[(9-Fluorenylmethoxycarbonyl)-L-isoleucyl]-2,2,5-trimethyl-4-oxazolidinecarboxylic Acid; N-α-Fmoc-N-δ-(2,2,5-trimethyl-4-oxazolidinecarbonyl)-L-isoleucine; Fmoc-L-Ile-Oxazolidine; Fmoc-Ile-Oxz-OH; Oxazolidine-protected Fmoc-Isoleucine; (4S,5R)-2,2,5-Trimethyl-3-[(9H-fluoren-9-ylmethoxy)carbonylamino]-4-oxazolidinecarboxylic acid (Ile derivative)
EINECS	Contact for details

Quality Control

Our (4S,5R)-3-(Fmoc-Ile)-2,2,5-Trimethyl-Oxazolidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant to maintain stability and prevent degradation. Keep away from heat and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.