Description

n-Fmoc-Freidinger's Lactam is a specialized, high-purity building block used in advanced peptide and peptidomimetic synthesis. This compound matters for its critical role in constructing conformationally constrained peptide scaffolds, enabling the development of novel bioactive molecules with enhanced stability and specificity. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, particularly for targeting protein-protein interactions and developing next-generation therapeutics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the incorporation of Freidinger lactam motifs, which introduce β-turn mimetics into peptide chains.
• Peptidomimetic Drug Discovery: Used to create constrained peptide analogs with improved metabolic stability, bioavailability, and receptor selectivity for therapeutic candidates.
• Medicinal Chemistry Research: Serves as a versatile scaffold in the synthesis of compound libraries for high-throughput screening against various biological targets.
• Protease Inhibitor Development: Employed in the design and synthesis of transition-state analog inhibitors for enzymes like aspartyl proteases.
• Chemical Biology Probes: Facilitates the creation of labeled or tagged peptidomimetics for studying biological pathways and protein functions.
• Academic & Institutional R&D: A fundamental reagent for graduate-level and post-doctoral research in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	n-Fmoc-Freidinger's Lactam
CAS No.	957507-85-6
Molecular Formula	C₂₀H₁₉NO₅
Molecular Weight	353.37 g/mol
Synonyms	Fmoc-Freidinger Lactam; (3S,6S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-propen-1-yl)-2,5-diketopiperazine; 1-Fmoc-3-allyl-2,5-diketopiperazine; (3S,6S)-1-(Fmoc)-3-allyl-2,5-diketopiperazine; (3S,6S)-3-Allyl-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperazine-2,5-dione; Freidinger Lactam Fmoc derivative; N-α-Fmoc-3-allyl-2,5-diketopiperazine
EINECS	Contact for details

Quality Control

Our n-Fmoc-Freidinger's Lactam is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral integrity. Certificates of Analysis (COA) detailing specific results for identity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.