Description

(E)-Ethyl 2-(Piperidin-3-Ylidene)Acetate Hydrochloride is a high-purity chemical intermediate with a defined stereochemistry, essential for advanced synthetic pathways. Its value lies in its role as a versatile building block for constructing complex nitrogen-containing heterocycles, a core structural motif in many active pharmaceutical ingredients. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Organic Synthesis Building Block: Employed in the construction of complex piperidine-based alkaloids and other nitrogen heterocycles.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.

Basic Information

Product Name	(E)-Ethyl 2-(Piperidin-3-Ylidene)Acetate Hydrochloride
CAS No.	957472-01-4
Molecular Formula	C9H16ClNO2
Molecular Weight	205.68 g/mol
Synonyms	Ethyl (3E)-3-piperidin-3-ylideneacetate hydrochloride; Ethyl (E)-3-(piperidin-3-ylidene)propanoate hydrochloride; 3-Piperidinylideneacetic acid ethyl ester hydrochloride; (E)-Ethyl 3-(piperidin-3-ylidene)propionate hydrochloride; 957472-01-4; (E)-Ethyl β-(3-piperidylidene)propionate HCl
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 2-(Piperidin-3-Ylidene)Acetate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.