Description

2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is a high-value, synthetically versatile organoboron building block. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated biaryl motifs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atom and boronate ester group enable precise structural modification.
• Material Science: Serves as a monomer or building block for advanced organic electronic materials, such as OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: Essential for methodological development and complex molecule synthesis in academic laboratories and CROs/CDMOs.
• Ligand Synthesis: Used to prepare novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide
CAS No.	957346-57-5
Molecular Formula	C13H17BFNO3
Molecular Weight	265.09 g/mol
Synonyms	4-Carbamoyl-3-fluorophenylboronic acid pinacol ester; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid amide; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluorobenzamide; 2-Fluoro-4-(pinacolatoboryl)benzamide; 2-Fluoro-4-Boronobenzamide Pinacol Ester; 4-(Pinacolboronato)-2-fluorobenzamide; 2-Fluoro-4-Bpin-benzamide
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.