Description

4-Bromo-3-Cyclopropyl-1H-Pyrazole is a high-value brominated heterocyclic building block with significant utility in advanced organic synthesis. This compound is prized for its unique molecular architecture, which combines a reactive pyrazole core with a bromine substituent and a cyclopropyl group, enabling precise structural modifications. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates. Its role is critical in medicinal chemistry for scaffold diversification and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used to construct advanced intermediates for new-generation herbicides, fungicides, and insecticides with improved efficacy.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science Research: Employed in the development of specialty polymers and organic electronic materials requiring tailored heterocyclic components.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig amination.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	4-Bromo-3-Cyclopropyl-1H-Pyrazole
CAS No.	957345-28-7
Molecular Formula	C6H7BrN2
Molecular Weight	187.04 g/mol
Synonyms	4-Bromo-3-cyclopropyl-1H-pyrazole; 3-Cyclopropyl-4-bromo-1H-pyrazole; 1H-Pyrazole, 4-bromo-3-cyclopropyl-; 4-Bromo-3-cyclopropylpyrazole; 957345-28-7; 4-Br-3-CPP; 4-Bromo-3-cyclopropylpyrazole (CAS 957345-28-7)
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-3-Cyclopropyl-1H-Pyrazole is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity, and impurity profiles. Our standard quality commitment ensures the material meets the stringent requirements for research and development use in regulated industries. Specifications can be developed to align with customer-specific pharmacopeial or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.