Description

(2S,4R)-1-(tert-Butoxycarbonyl)-4-(2-(Trifluoromethyl)Benzyl)Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a chiral pyrrolidine scaffold, a trifluoromethylbenzyl group, and a Boc-protected amine. This compound is a critical advanced pharmaceutical intermediate (API) designed for the synthesis of complex, biologically active molecules, particularly in drug discovery and development. It is essential for medicinal chemists and process R&D teams in the pharmaceutical and biotechnology industries seeking to incorporate a rigid, fluorinated chiral building block into novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Protease Inhibitor Synthesis: Used as a core structural component in the design and synthesis of protease inhibitors, leveraging the pyrrolidine carboxylic acid motif.
• Peptidomimetic Drug Development: Acts as a constrained, non-proteinogenic amino acid analog for creating stable and bioavailable peptidomimetics.
• Chemical Biology & Probe Design: Employed in constructing chemical probes and tool compounds for studying enzyme function and biological pathways, utilizing the fluorine label for potential tracking.
• Asymmetric Synthesis Building Block: Provides a source of chiral induction in multi-step organic syntheses for complex natural products and fine chemicals.
• Process Chemistry & Scale-Up: Supplied under cGMP-compatible conditions for use in late-stage process development and commercial manufacturing campaigns.

Basic Information

Product Name	(2S,4R)-1-(tert-Butoxycarbonyl)-4-(2-(Trifluoromethyl)Benzyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	957311-13-6
Molecular Formula	C18H22F3NO4
Molecular Weight	373.37 g/mol
Synonyms	Boc-4-[(2-Trifluoromethyl)phenylmethyl]-L-proline; (2S,4R)-1-Boc-4-(2-(Trifluoromethyl)benzyl)pyrrolidine-2-carboxylic acid; 1-[(1,1-Dimethylethoxy)carbonyl]-4-[[2-(trifluoromethyl)phenyl]methyl]-2-pyrrolidinecarboxylic acid, (2S,4R)-; (2S,4R)-1-(Boc)-4-(2-(Trifluoromethyl)benzyl)proline; (2S,4R)-Boc-4-(2-Trifluoromethylbenzyl)proline; 957311-13-6; L-Proline, 1-[(1,1-dimethylethoxy)carbonyl]-4-[[2-(trifluoromethyl)phenyl]methyl]-, (2S,4R)-
EINECS	Contact for details

Quality Control

Every batch of (2S,4R)-1-(tert-Butoxycarbonyl)-4-(2-(Trifluoromethyl)Benzyl)Pyrrolidine-2-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are available for every shipment. Our quality systems are designed to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.