Description

(R)-5-Amino-1,3-Dihydrospiro[Indene-2,3'-Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One is a high-purity, chiral spirocyclic organic compound that serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern organic synthesis. Its unique three-dimensional fused-ring structure makes it a valuable scaffold for medicinal chemistry research, particularly in the development of targeted small-molecule therapeutics. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel drug candidates for neurological and oncological applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the research and development of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a privileged spirocyclic scaffold for structure-activity relationship (SAR) studies and high-throughput screening libraries to discover new bioactive molecules.
• Asymmetric Synthesis: Employed in chiral synthesis and catalysis studies due to its defined (R)-configuration, enabling the production of enantiomerically pure compounds.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and protein-ligand interactions.
• Process Chemistry Development: Used in scale-up and optimization studies for the commercial manufacturing route of complex drug molecules.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	(R)-5-Amino-1,3-Dihydrospiro[Indene-2,3'-Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One
CAS No.	957130-49-3
Molecular Formula	C17H16N4O
Molecular Weight	292.34 g/mol
Synonyms	(R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; (R)-5-Amino-1,3-dihydro-2'H-spiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'-one; (R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridine]-2'(1'H)-one; Spiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one, 5-amino-1,3-dihydro-, (R)-; (R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'-one; 957130-49-3; (R)-enantiomer of 5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
EINECS	Contact for details

Quality Control

Our (R)-5-Amino-1,3-Dihydrospiro[Indene-2,3'-Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric purity and identity verification by spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, assay, and impurity profiles to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.