Description

3-Hydroxy-5-(Trifluoromethoxy)Phenylboronic Acid is a specialized boronic acid derivative that serves as a crucial building block in modern synthetic chemistry. Its unique structure, featuring both a phenolic hydroxyl and a trifluoromethoxy group, makes it a valuable precursor for constructing complex molecules with enhanced properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethoxy pharmacophore for improved metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the phenylboronic acid moiety enables efficient carbon-carbon bond formation.
• Material Science Research: Employed in the creation of advanced organic materials, such as ligands for catalysts or monomers for specialty polymers.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a versatile boronic acid partner for palladium-catalyzed coupling with aryl or vinyl halides, a cornerstone reaction in medicinal chemistry.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and bioconjugates due to the reactivity of the boronic acid group.

Basic Information

Product Name	3-Hydroxy-5-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	957120-22-8
Molecular Formula	C7H6BF3O4
Molecular Weight	221.93 g/mol
Synonyms	[3-Hydroxy-5-(trifluoromethoxy)phenyl]boronic acid; 5-(Trifluoromethoxy)-3-hydroxybenzeneboronic acid; 3-Hydroxy-5-trifluoromethoxybenzeneboronic acid; Boronic acid, B-[3-hydroxy-5-(trifluoromethoxy)phenyl]-; 3-Borono-5-(trifluoromethoxy)phenol
EINECS	Contact for details

Quality Control

We maintain rigorous quality control protocols for all our boronic acid derivatives. Each batch of 3-Hydroxy-5-(Trifluoromethoxy)Phenylboronic Acid is analyzed to ensure high purity and consistency, suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.