Description

4-Chloro-3-Trifluoromethylthioanisole is a high-value, multi-functional aromatic building block characterized by its unique combination of chlorine, trifluoromethylthio, and methoxy substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced agrochemicals and pharmaceuticals, where its structural motifs are leveraged to modulate biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the fine chemical, crop protection, and pharmaceutical industries seeking to develop novel active ingredients with enhanced efficacy and patentability.

Application

• Agrochemical Intermediate: A key synthon for the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethylthio group can improve lipophilicity and metabolic stability.
• Pharmaceutical Building Block: Used in medicinal chemistry for the synthesis of drug candidates, particularly in areas targeting central nervous system (CNS) disorders and oncology.
• Material Science Research: Serves as a precursor for specialized monomers or ligands in the development of advanced polymers and catalysts.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex aryl ether motifs into target molecules.
• Liquid Crystal & OLED Materials: Potential use in the synthesis of electronic materials requiring specific dipole moments and steric profiles.

Basic Information

Product Name	4-Chloro-3-Trifluoromethylthioanisole
CAS No.	957066-04-5
Molecular Formula	C8H6ClF3OS
Molecular Weight	242.64 g/mol
Synonyms	1-Chloro-2-methoxy-4-(trifluoromethylthio)benzene; 4-Chloro-3-((trifluoromethyl)thio)anisole; 2-Methoxy-5-chlorophenyl trifluoromethyl sulfide; Benzene, 1-chloro-2-methoxy-4-[(trifluoromethyl)thio]-; 5-Chloro-2-methoxy-α,α,α-trifluorothioanisole
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Trifluoromethylthioanisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment ensures material consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.