Description

2-Chloro-4-Fluoro-5-Methoxycarbonylphenylboronic Acid is a high-purity boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in its role as a key intermediate in cross-coupling reactions, enabling the efficient synthesis of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

This versatile boronic acid ester is primarily employed as a sophisticated synthetic intermediate. Its key applications include:

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: An essential reagent in academic and industrial R&D labs for constructing complex biaryl and heterobiaryl structures.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for commercial active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Chloro-4-Fluoro-5-Methoxycarbonylphenylboronic Acid
CAS No.	957066-03-4
Molecular Formula	C8H7BClFO4
Molecular Weight	231.40 g/mol
Synonyms	(2-Chloro-4-fluoro-5-(methoxycarbonyl)phenyl)boronic acid; 5-Borono-2-chloro-4-fluoro-benzoic acid methyl ester; Methyl 5-borono-2-chloro-4-fluorobenzoate; 2-Chloro-4-fluoro-5-(methoxycarbonyl)benzeneboronic acid; Boronic acid, B-[2-chloro-4-fluoro-5-(methoxycarbonyl)phenyl]-
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-4-Fluoro-5-Methoxycarbonylphenylboronic Acid adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.