Description

3-(Benzyloxy)-2-Chloro-6-Fluorophenylboronic Acid is a high-purity boronic acid derivative serving as a critical building block in modern synthetic chemistry. This compound matters for its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific halogenated phenyl structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular architecture is crucial.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid partner for palladium-catalyzed cross-coupling reactions with aryl halides, a cornerstone methodology in medicinal and process chemistry.
• Ligand and Catalyst Development: Utilized as a building block for constructing sophisticated ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Acts as a synthetic handle for creating molecular probes and tags used in biochemical assays and diagnostic research.

Basic Information

Product Name	3-(Benzyloxy)-2-Chloro-6-Fluorophenylboronic Acid
CAS No.	957062-67-8
Molecular Formula	C₁₃H₁₁BClFO₃
Molecular Weight	279.49 g/mol
Synonyms	2-Chloro-6-fluoro-3-(phenylmethoxy)benzeneboronic acid; (3-(Benzyloxy)-2-chloro-6-fluorophenyl)boronic acid; B-[3-(Benzyloxy)-2-chloro-6-fluorophenyl]boronic acid; 3-Benzyloxy-2-chloro-6-fluorobenzeneboronic acid; 957062-67-8; AKOS005258065
EINECS	Contact for details

Quality Control

Our 3-(Benzyloxy)-2-Chloro-6-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) with full characterization data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.