Description

3-Borono-5-Hydroxybenzotrifluoride is a high-value trifluoromethylated arylboronic acid derivative, serving as a versatile bifunctional building block in advanced organic synthesis. Its unique structure, combining a boronic acid group and a hydroxyl group on a trifluoromethylated aromatic ring, enables precise cross-coupling reactions and the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those incorporating trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or linker due to its orthogonal reactive sites (boronic acid and phenol), useful for bioconjugation and affinity chromatography.
• Catalyst Ligand Development: The hydroxyl and boronic acid functionalities can be utilized to design novel ligands for transition metal catalysis.
• Fluorine Chemistry Research: A valuable substrate for studying the influence of the -CF3 group on reaction kinetics and regioselectivity in aromatic systems.

Basic Information

Product Name	3-Borono-5-Hydroxybenzotrifluoride
CAS No.	957062-66-7
Molecular Formula	C7H6BF3O3
Molecular Weight	205.93 g/mol
Synonyms	5-Hydroxy-3-(trifluoromethyl)phenylboronic acid; (5-Hydroxy-3-(trifluoromethyl)phenyl)boronic acid; 3-(Trifluoromethyl)-5-hydroxybenzeneboronic acid; 3-Trifluoromethyl-5-hydroxyphenylboronic acid; Boronic acid, B-[5-hydroxy-3-(trifluoromethyl)phenyl]-; 3-Borono-5-hydroxybenzotrifluoride; 3-CF3-5-OH-PhB(OH)2
EINECS	Contact for details

Quality Control

Our 3-Borono-5-Hydroxybenzotrifluoride is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.