Description

2-Chloro-3-Trifluoromethylphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, as well as in materials science for creating advanced organic electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, particularly those containing biaryl or heterobiaryl motifs common in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated trifluoromethylphenyl structures.
• Material Science Research: Serves as a precursor for synthesizing organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 2-chloro-3-(trifluoromethyl)phenyl group into target molecules.
• Chemical Biology & Probe Development: Useful for creating molecular probes and bioconjugates due to the reactivity of the boronic acid group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific boronic acid.

Basic Information

Product Name	2-Chloro-3-Trifluoromethylphenylboronic Acid
CAS No.	957061-11-9
Molecular Formula	C7H5BClF3O2
Molecular Weight	223.38 g/mol
Synonyms	(2-Chloro-3-(trifluoromethyl)phenyl)boronic acid; 2-Chloro-3-(trifluoromethyl)benzeneboronic acid; B-(2-Chloro-3-(trifluoromethyl)phenyl)boronic acid; 2-Chloro-alpha,alpha,α-trifluoro-m-tolylboronic acid; 957061-11-9; Boronic acid, B-[2-chloro-3-(trifluoromethyl)phenyl]-; 2-Chloro-3-trifluoromethylbenzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Trifluoromethylphenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and moisture content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.