Description

2-(2,2,2-Trifluoroethoxy)Phenylboronic Acid is a specialized organoboron compound featuring a phenyl ring substituted with both a boronic acid group and a trifluoroethoxy moiety. This unique structure makes it a valuable building block in modern synthetic chemistry, particularly for Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex molecules containing trifluoroethyl aryl ether pharmacophores.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring the trifluoroethoxy group for enhanced metabolic stability or lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the introduction of fluorine-containing groups can improve biological activity.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, liquid crystals, or polymers with specific fluorinated aromatic properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes, leveraging the boronic acid group for selective binding.
• Catalyst & Ligand Development: Can be used to develop new ligands or organocatalysts for asymmetric synthesis and other catalytic transformations.

Basic Information

Product Name	2-(2,2,2-Trifluoroethoxy)Phenylboronic Acid
CAS No.	957060-90-1
Molecular Formula	C8H8BF3O3
Molecular Weight	219.96 g/mol
Synonyms	[2-(2,2,2-Trifluoroethoxy)phenyl]boronic acid; 2-(Trifluoroethoxy)benzeneboronic acid; (2-(2,2,2-Trifluoroethoxy)phenyl)boronic acid; 2-Trifluoroethoxyphenylboronic Acid; Boronic acid, B-[2-(2,2,2-trifluoroethoxy)phenyl]-; 957060-90-1; 2-(2,2,2-Trifluoroethoxy)benzeneboronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-(2,2,2-Trifluoroethoxy)Phenylboronic Acid is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening a new container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.