Description

2,3-Difluoro-5-Nitrophenylboronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its value lies in its unique molecular structure, which combines a boronic acid functional group with electron-withdrawing nitro and fluorine substituents, making it a critical building block for constructing complex molecules. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in creating complex biaryl structures via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new herbicides and pesticides, where the difluoro-nitrophenyl moiety can impart specific biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its structure can tune electronic properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and sensors that leverage boronic acid's affinity for diols.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	2,3-Difluoro-5-Nitrophenylboronic Acid
CAS No.	957060-82-1
Molecular Formula	C6H4BF2NO4
Molecular Weight	202.91 g/mol
Synonyms	(2,3-Difluoro-5-nitrophenyl)boronic acid; 2,3-Difluoro-5-nitrobenzeneboronic acid; 5-Nitro-2,3-difluorophenylboronic acid; Boronic acid, B-(2,3-difluoro-5-nitrophenyl)-; 957060-82-1; 2,3-Difluoro-5-nitrophenyl-B(OH)2
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-5-Nitrophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to relevant industry standards to support our customers' research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.