Description

3-(Benzyloxy)-4-Fluorophenylboronic Acid is a high-purity boronic acid derivative, a key building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing active pharmaceutical ingredients (APIs), novel crop protection agents, and organic electronic materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, especially those containing fluorinated biaryl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorinated phenyl ring contributes to biological activity and environmental persistence profiles.
• Material Science Research: Serves as a monomer or building block for constructing organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The principal application is as a boronic acid reagent for palladium-catalyzed carbon-carbon bond formation with aryl halides or triflates.
• Chemical Biology & Probe Development: Utilized in synthesizing fluorescent tags, molecular probes, and bioconjugation reagents for diagnostic and research applications.
• Academic & Process R&D: A valuable tool for methodology development and scaling new synthetic routes in university and industrial research laboratories.

Basic Information

Product Name	3-(Benzyloxy)-4-Fluorophenylboronic Acid
CAS No.	957034-74-1
Molecular Formula	C₁₃H₁₂BFO₃
Molecular Weight	246.05 g/mol
Synonyms	4-Fluoro-3-(phenylmethoxy)benzeneboronic Acid; (3-Benzyloxy-4-fluorophenyl)boronic Acid; B-[3-(Benzyloxy)-4-fluorophenyl]boronic Acid; 3-Benzyloxy-4-fluorobenzeneboronic Acid; 4-Fluoro-3-benzyloxybenzeneboronic Acid; 3-(Benzyloxy)-4-fluorobenzeneboronic Acid; 3-(Benzyloxy)-4-fluorophenyl-Boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 3-(Benzyloxy)-4-Fluorophenylboronic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions and regulatory filings. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports applications in cGMP and non-GMP environments alike.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (argon or nitrogen) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.