Description

Biotin-Peg11-Azide CAS NO 956494-20-5 is a high-purity, heterobifunctional crosslinker designed for advanced bioconjugation and click chemistry applications. Its core value lies in the precise combination of biotin for strong streptavidin/avidin binding and a terminal azide group for efficient, copper-catalyzed or strain-promoted cycloaddition with alkynes. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation who require reliable, site-specific labeling of biomolecules.

Application

• ADC (Antibody-Drug Conjugate) Development: Site-specific conjugation of cytotoxic payloads or imaging agents to monoclonal antibodies via the azide-alkyne click reaction, with subsequent purification or detection enabled by the biotin tag.
• Proteomics & Biomarker Discovery: Labeling of proteins, peptides, or cell surface glycans for pull-down assays, affinity purification, or enrichment using streptavidin-coated beads or columns.
• Diagnostic Kit Manufacturing: Conjugation of reporter enzymes (e.g., HRP) or fluorescent dyes to antibodies or oligonucleotides for ELISA, lateral flow assays, or in-situ hybridization, facilitating sensitive detection.
• Cell Biology & Imaging: Labeling of cell surface receptors or intracellular targets with fluorescent probes for tracking, localization, and live-cell imaging studies.
• Material Science & Surface Functionalization: Modification of nanoparticles, polymers, or biosensor surfaces with biotin for creating ordered, bioactive interfaces.
• Drug Delivery System Research: Construction of targeted liposomal or polymeric nanocarriers where the biotin moiety enables specific targeting to overexpressed receptors on diseased cells.

Basic Information

Product Name	Biotin-Peg11-Azide
CAS No.	956494-20-5
Molecular Formula	C43H80N8O15S
Molecular Weight	957.2 g/mol
Synonyms	Biotin-PEG11-N3; Biotin-PEG11-N3; Biotin-Polyethylene glycol11-Azide; 5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide; Biotin-PEG11 Azide; Azido-PEG11-Biotin; N3-PEG11-Biotin
EINECS	Contact for details

Quality Control

Our Biotin-Peg11-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, supporting its use in research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, methanol; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.