Description

Aa-Pegn-Nh2 2K, 5K, 10K, 20K CAS NO 956493-68-8 is a heterobifunctional polyethylene glycol (PEG) derivative featuring an amine group at one terminus, widely used as a versatile linker in bioconjugation and pharmaceutical development. This compound is critical for creating stable, water-soluble conjugates that enhance the pharmacokinetic properties of therapeutic agents. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications in drug delivery, surface modification, and diagnostic assay development.

Application

• Bioconjugation and PEGylation: A key reagent for attaching PEG chains to peptides, proteins, antibodies, and other biomolecules to improve solubility, reduce immunogenicity, and extend circulation half-life.
• Drug Delivery Systems: Used as a functional linker in the synthesis of prodrugs, antibody-drug conjugates (ADCs), and nanoparticle-based delivery platforms.
• Surface Functionalization: Enables the amine-functionalization of surfaces, particles, and materials for subsequent coupling with biomolecules or other functional groups in biosensor and diagnostic device manufacturing.
• Crosslinking Agent: Serves as a hydrophilic spacer and crosslinker in hydrogel formation and polymer network synthesis for tissue engineering and controlled release applications.
• Diagnostic Reagent Synthesis: Employed in the preparation of labeled probes and contrast agents for imaging and diagnostic assays.
• Affinity Chromatography: Used to modify chromatography resins and matrices for the purification of specific biomolecules.

Basic Information

Product Name	Aa-Pegn-Nh2 2K, 5K, 10K, 20K
CAS No.	956493-68-8
Molecular Formula	CnH2n+2On+1 (PEG core) *Varies by molecular weight*
Molecular Weight	2,000 Da (2K), 5,000 Da (5K), 10,000 Da (10K), 20,000 Da (20K) (Nominal)
Synonyms	α-Amino-ω-hydroxy Polyethylene Glycol; Amine-PEG-OH; NH2-PEG-OH; Heterobifunctional PEG Amine; PEG-diamine (heterobifunctional); Amino Poly(ethylene glycol) Hydroxyl; Poly(oxy-1,2-ethanediyl), α-amino-ω-hydroxy-; Amino-PEG-Alcohol
EINECS	Contact for details

Quality Control

Our Aa-Pegn-Nh2 products are manufactured under strict quality management systems. Each batch is characterized to ensure critical parameters such as molecular weight distribution (PDI), amine functionalization degree, and purity meet stringent specifications. Certificates of Analysis (COA) detailing results from NMR, HPLC, and titration assays are provided with every shipment to guarantee consistency and support your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen), desiccate prior to sealing.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Molecular Weight (Nominal)	2K, 5K, 10K, 20K
Polydispersity Index (PDI)	≤ 1.05 (by GPC)
Assay (Amine Content)	≥ 95% (by titration/NMR)
Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.