Description

(3R,4R)-Rel-tert-Butyl 4-Hydroxy-3-Methylpiperidine-1-Carboxylate CAS NO 955028-90-7 is a high-purity, chiral piperidine derivative serving as a critical advanced pharmaceutical intermediate (API intermediate). Its value lies in providing a stereochemically defined building block essential for the synthesis of complex, biologically active molecules, ensuring high enantiomeric purity in the final active pharmaceutical ingredient (API). This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutics, particularly in areas requiring precise chiral control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for central nervous system (CNS) and antiviral targets.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to construct complex molecular architectures with defined three-dimensional configurations.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and bespoke intermediates.

Basic Information

Product Name	(3R,4R)-Rel-tert-Butyl 4-Hydroxy-3-Methylpiperidine-1-Carboxylate
CAS No.	955028-90-7
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	1-Boc-4-hydroxy-3-methylpiperidine (rel-(3R,4R)-form); tert-Butyl (3R,4R)-4-hydroxy-3-methylpiperidine-1-carboxylate; (3R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-3-methylpiperidine; 4-Hydroxy-3-methylpiperidine-1-carboxylic acid tert-butyl ester; BOC-4-Hydroxy-3-methylpiperidine; 955028-90-7; (3R,4R)-4-Hydroxy-3-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (3R,4R)-Rel-tert-Butyl 4-Hydroxy-3-Methylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent moisture absorption. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.