Description

4-Bromo-1-Difluoromethoxy-2-Trifluoromethyl-Benzene is a high-value, multi-functional fluorinated aromatic building block. Its unique structure, featuring bromine, difluoromethoxy, and trifluoromethyl substituents, makes it a critical intermediate for introducing fluorine atoms into complex molecules, which is essential for modulating their physicochemical and biological properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-inflammatory agents, and antiviral therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability, metabolic stability, and overall efficacy.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials requiring specific dielectric or surface properties.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Fluorine Chemistry Research: An important reagent for academic and industrial research focused on exploring new methodologies in organofluorine chemistry.

Basic Information

Item	Details
Product Name	4-Bromo-1-Difluoromethoxy-2-Trifluoromethyl-Benzene
CAS No.	954236-13-6
Molecular Formula	C9H4BrF5O
Molecular Weight	303.03 g/mol
Synonyms	4-Bromo-α,α-difluoro-2-(trifluoromethyl)anisole; 1-Bromo-4-(difluoromethoxy)-2-(trifluoromethyl)benzene; 2-Trifluoromethyl-4-bromo-1-difluoromethoxybenzene; 4-Bromo-2-trifluoromethyl-1-difluoromethoxybenzene; Benzene, 4-bromo-1-(difluoromethoxy)-2-(trifluoromethyl)-; 954236-13-6 (CAS Name)
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-Difluoromethoxy-2-Trifluoromethyl-Benzene is produced and analyzed under strict quality management protocols. We guarantee high-purity material suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to ensure full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.