Description

1-Bromo-2-Difluoromethoxy-3-Methyl-Benzene is a high-value, multi-functional aromatic building block characterized by its unique combination of bromine and difluoromethoxy substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for applications in catalysis, ligand synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluoromethoxy group can improve biological activity and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis, useful in cross-coupling and other organic transformations.
• Material Science Research: Employed in the synthesis of monomers and functionalized aromatics for advanced polymers, liquid crystals, and electronic materials.
• Chemical Biology Probes: Useful for tagging and modifying biomolecules in research due to the reactivity of the bromine atom and the properties of the fluorinated ether.

Basic Information

Product Name	1-Bromo-2-Difluoromethoxy-3-Methyl-Benzene
CAS No.	954236-08-9
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	2-Bromo-1-(difluoromethoxy)-3-methylbenzene; 3-Methyl-2-(difluoromethoxy)bromobenzene; 1-Bromo-2-(difluoromethoxy)-3-methylbenzene; 2-(Difluoromethoxy)-3-methylbromobenzene; Benzene, 1-bromo-2-(difluoromethoxy)-3-methyl-; 3-Methyl-2-difluoromethoxybromobenzene
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-2-Difluoromethoxy-3-Methyl-Benzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to confirm identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support customer audits and regulatory documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.