Description

1-Bromo-2-Difluoromethoxy-3-Fluoro-Benzene is a high-purity, multi-functional fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine and difluoromethoxy substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the difluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new methodologies in fluorination and the effects of fluorine on molecular properties.

Basic Information

Product Name	1-Bromo-2-Difluoromethoxy-3-Fluoro-Benzene
CAS No.	954235-98-4
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	2-Bromo-1-Fluoro-3-(Difluoromethoxy)Benzene; 3-Bromo-2-Fluorophenyl Difluoromethyl Ether; 1-Bromo-2-(Difluoromethoxy)-3-Fluorobenzene; 2-(Difluoromethoxy)-1-Fluoro-3-Bromobenzene; Benzene, 1-bromo-2-(difluoromethoxy)-3-fluoro-; 3-Fluoro-2-(difluoromethoxy)bromobenzene
EINECS	Contact for details

Quality Control

Every batch of our 1-Bromo-2-Difluoromethoxy-3-Fluoro-Benzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to ensure compliance with your R&D and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.