Description

2-Bromo-1-Difluoromethoxy-4-Methyl-Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines bromine and difluoromethoxy substituents on a methylbenzene core, enabling precise structural modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the difluoromethoxy pharmacophore.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers and liquid crystals with tailored electronic properties.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination.
• Fluorine Chemistry Exploration: An important substrate for studying the effects of fluorine substitution on aromatic systems and reaction pathways.
• Chemical Library Development: Used in high-throughput and combinatorial chemistry to build diverse compound libraries for screening.

Basic Information

Product Name	2-Bromo-1-Difluoromethoxy-4-Methyl-Benzene
CAS No.	954235-93-9
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	2-Bromo-α,α-difluoro-4-methylanisole; 1-Bromo-2-(difluoromethoxy)-5-methylbenzene; 4-Methyl-2-bromodifluoromethoxybenzene; Benzene, 2-bromo-1-(difluoromethoxy)-4-methyl-; 2-Bromo-4-methyl-1-(difluoromethoxy)benzene; 1-(Difluoromethoxy)-2-bromo-4-methylbenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-Difluoromethoxy-4-Methyl-Benzene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.