Description

4-Bromo-2-Difluoromethoxy-1-Fluoro-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a difluoromethoxy group, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for introducing fluorinated motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the difluoromethoxy and halogen substituents contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials, where its structure can influence dielectric anisotropy and luminescent properties.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying structure-activity relationships (SAR) and the effects of multiple fluorine atoms in medicinal and material chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for use in client-directed custom synthesis projects requiring specialized fluorinated intermediates.

Basic Information

Product Name	4-Bromo-2-Difluoromethoxy-1-Fluoro-Benzene
CAS No.	954235-78-0
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	1-Bromo-4-difluoromethoxy-2-fluorobenzene; 2-Fluoro-4-bromo-1-(difluoromethoxy)benzene; 4-Bromo-1-fluoro-2-(difluoromethoxy)benzene; Benzene, 4-bromo-2-(difluoromethoxy)-1-fluoro-; 954235-78-0; 4-Bromo-2-difluoromethoxy-1-fluorobenzene
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Difluoromethoxy-1-Fluoro-Benzene is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting research and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light) as indicated in its chemical properties.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.