Description

3-(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-(2-Trifluoromethyl-Phenyl)-Propanoic Acid is a specialized, high-purity Fmoc-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the precise construction of complex peptide and peptidomimetic structures, particularly those requiring the incorporation of a trifluoromethylphenyl side chain for enhanced biological activity and metabolic stability. This compound is essential for research and development chemists in the pharmaceutical, biotechnology, and agrochemical sectors, where it is used to develop novel therapeutic agents, diagnostic tools, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of custom peptides containing the 2-(trifluoromethyl)phenylalanine residue.
• Pharmaceutical R&D: Building block for the development of novel drug candidates, including protease inhibitors, receptor agonists/antagonists, and other peptidomimetics where the CF3 group modulates lipophilicity and binding affinity.
• Chemical Biology & Proteomics: Used to synthesize peptide probes, substrates, and inhibitors for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Intermediate in the synthesis of bioactive peptides and peptide-like compounds with potential herbicidal or insecticidal activity.
• Material Science: Potential monomer for creating specialized polymers and functional materials with unique surface properties.
• Custom Synthesis Services: A high-value starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis.

Basic Information

Product Name	3-(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-(2-Trifluoromethyl-Phenyl)-Propanoic Acid
CAS No.	954225-58-2
Molecular Formula	C25H20F3NO4
Molecular Weight	455.43 g/mol
Synonyms	Fmoc-2-(Trifluoromethyl)Phenylalanine; Fmoc-2-Tfm-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-(trifluoromethyl)phenyl)-L-alanine; Fmoc-3-(2-Trifluoromethylphenyl)alanine; Nα-Fmoc-2-(Trifluoromethyl)-L-phenylalanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethyl)phenyl)propanoic acid; Fmoc-L-2-Tfm-Phe; Fmoc-2-CF3-Phe-OH
EINECS	Contact for details

Quality Control

Our 3-(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-(2-Trifluoromethyl-Phenyl)-Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and spectroscopic identification. We provide Certificates of Analysis (COA) detailing all specifications, ensuring the material meets the stringent requirements for advanced synthetic applications. Custom purity grades, including >98% and >99%, are available to suit specific research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For optimal performance, allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.