Description

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(2H-Tetrazol-5-Yl)Propanoic Acid is a high-purity, non-natural amino acid derivative designed for advanced pharmaceutical research and peptide synthesis. This compound is a critical building block for the development of novel peptide-based therapeutics and diagnostic agents, offering precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on creating innovative drug candidates and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative for the controlled incorporation of the tetrazole functional group into peptide chains.
• Peptidomimetic Drug Discovery: Serves as a key intermediate in the design and synthesis of peptidomimetics, where the tetrazole moiety acts as a bioisostere for carboxylic acids or other functional groups.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways, including cardiovascular and metabolic disorders.
• Chemical Biology Probes: Enables the creation of specialized probes for studying enzyme-substrate interactions and protein function due to its unique tetrazole side chain.
• Ligand Development: Employed in the development of novel ligands for receptors and enzymes, leveraging the metal-coordinating and hydrogen-bonding properties of the tetrazole ring.

Basic Information

Product Name	(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(2H-Tetrazol-5-Yl)Propanoic Acid
CAS No.	954147-35-4
Molecular Formula	C19H17N5O4
Molecular Weight	379.37 g/mol
Synonyms	Fmoc-Tetrazolylalanine; Fmoc-3-(2H-Tetrazol-5-yl)-L-alanine; Fmoc-L-3-(2H-Tetrazol-5-yl)alanine; (S)-2-(((9H-Fluoren-9-ylmethoxy)carbonyl)amino)-3-(1H-tetrazol-5-yl)propanoic acid; Fmoc-3-(1H-Tetrazol-5-yl)-L-alanine; Fmoc-Tza-OH; Fmoc-L-Tza-OH; 5-L-2-[(9H-Fluoren-9-ylmethoxycarbonyl)amino]-3-(1H-tetrazol-5-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our production of (S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(2H-Tetrazol-5-Yl)Propanoic Acid adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. All materials are subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.