Description

1-Dicyclohexylphosphino-1′-{(S)-{(Sp)-2-[(R)-1-(Dimethylamino)Ethyl]Ferrocenyl}Phenylphosphino}Ferrocene is a highly sophisticated, chiral ferrocenylphosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and high catalytic activity in a range of transition-metal-catalyzed reactions, enabling the production of complex chiral molecules with high purity. This ligand is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who are developing advanced synthetic routes for active pharmaceutical ingredients (APIs), natural products, and specialty chemicals.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for synthesizing chiral amines, alcohols, and amino acid derivatives.
• Asymmetric Cross-Coupling Reactions: Facilitates C-C and C-X bond-forming reactions with high stereocontrol, such as Suzuki-Miyaura and Buchwald-Hartwig amination.
• Pharmaceutical Intermediate Synthesis: Key component in the catalytic synthesis of chiral building blocks for novel drug candidates and established APIs.
• Agrochemical Product Development: Used in the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Fragrance Manufacturing: Enables the efficient and selective production of high-value chiral flavor and fragrance compounds.
• Academic and Industrial R&D: A vital tool for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	1-Dicyclohexylphosphino-1′-{(S)-{(Sp)-2-[(R)-1-(Dimethylamino)Ethyl]Ferrocenyl}Phenylphosphino}Ferrocene
CAS No.	952586-19-5
Molecular Formula	C46H55Fe2NP2
Molecular Weight	795.58 g/mol
Synonyms	(S,Sp,R)-JOSIPHOS SL-J009-1; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine; Josiphos SL-J009-1; (R)-(S)-JOSIPHOS SL-J009-1; (S)-1-[(R)-2-[Bis(cyclohexyl)phosphino]ferrocenyl]ethyldimethylamine; Chiral Ferrocenylphosphine Ligand J009-1; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldimethylamine; (S,Sp,R)-JOSIPHOS-type ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and controlled under strict quality management to ensure consistency and performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity confirmation via advanced analytical techniques. Our quality systems support development under cGMP guidelines for pharmaceutical applications, and we comply with global regulatory frameworks including REACH.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized and moisture-sensitive; allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.