Description

5-Fluoro-6-Methylpyridine-2-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for constructing complex molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated pyridine cores found in active pharmaceutical ingredients (APIs), leveraging the Suzuki reaction for efficient library synthesis and lead optimization.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorinated methylpyridine moiety imparts desirable biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized bidentate or monodentate ligands used in homogeneous catalysis and material science applications.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs or organic photovoltaics, where precise molecular architecture is required.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or bioconjugates for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	5-Fluoro-6-Methylpyridine-2-Boronic Acid Pinacol Ester
CAS No.	952403-32-6
Molecular Formula	C₁₂H₁₇BFNO₂
Molecular Weight	237.08 g/mol
Synonyms	5-Fluoro-6-methylpyridine-2-boronic acid pinacol ester; 2-(5-Fluoro-6-methyl-2-pyridinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (5-Fluoro-6-methylpyridin-2-yl)boronic acid pinacol ester; 5-Fluoro-6-methyl-2-pyridineboronic acid pinacol ester; Pinacol (5-fluoro-6-methylpyridin-2-yl)boronate; Boronic acid, B-(5-fluoro-6-methyl-2-pyridinyl)-, 1,1-dimethylethyl ester; 952403-32-6
EINECS	Contact for details

Quality Control

Our 5-Fluoro-6-Methylpyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, identity confirmation (by NMR and HPLC), and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system supports compliance with global regulatory standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.