Description

Boc-Ile-Aib-Oh is a protected dipeptide building block featuring the amino acids isoleucine (Ile) and the non-proteinogenic aminoisobutyric acid (Aib). This compound is essential for the solid-phase and solution-phase synthesis of complex peptides, particularly those requiring conformational constraints or enhanced metabolic stability. It is a critical raw material for research and development in pharmaceutical discovery, enabling the creation of novel therapeutic peptides and peptidomimetics.

Application

• Peptide Synthesis: A fundamental building block for the controlled elongation of peptide chains in both research and GMP manufacturing.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based drugs, including antimicrobials, hormones, and enzyme inhibitors.
• Peptidomimetic Design: The incorporation of Aib induces specific helical conformations, making it valuable for creating stable peptide mimics with improved bioavailability.
• Bioconjugation & Labeling: Serves as a precursor for creating labeled peptides for diagnostic and research applications.
• Academic & Institutional Research: A key reagent for studying peptide structure-activity relationships (SAR) and folding.
• Custom Peptide Service Providers: A high-purity starting material for companies offering bespoke peptide synthesis services.

Basic Information

Product Name	Boc-Ile-Aib-Oh
CAS No.	952400-12-3
Molecular Formula	C₁₄H₂₆N₂O₅
Molecular Weight	302.37 g/mol
Synonyms	Boc-Ile-Aib-OH; (2S)-2-[[(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-methylpentanoyl]amino]-2-methylpropanoic acid; N-(tert-Butoxycarbonyl)-L-isoleucyl-2-aminoisobutyric acid; Boc-L-Ile-Aib-OH; tert-Butyloxycarbonyl-L-isoleucyl-aminoisobutyric acid; Boc-Ile-Aib; BOC-ILE-AIB-OH; Boc-Ile-α-aminoisobutyric acid
EINECS	Contact for details

Quality Control

Our Boc-Ile-Aib-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0%
Optical Rotation	-20° to -25° (c=1, in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.