Description

D-Proline, 1-Methyl-5-Oxo- is a high-purity, non-natural amino acid derivative characterized by its specific stereochemistry and functional groups. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the creation of complex molecules with precise three-dimensional structures. It is essential for research and development in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), peptide mimetics, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the asymmetric synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used in medicinal chemistry to design and synthesize peptide analogs with enhanced metabolic stability and bioavailability.
• Asymmetric Catalysis: Employed as a precursor or ligand in the development of chiral catalysts for stereoselective reactions.
• Agrochemical Synthesis: A building block for creating novel, chiral pesticides and herbicides with specific modes of action.
• Biochemical Research: Utilized in enzymatic studies and as a probe to investigate biological pathways involving proline metabolism.
• Fine Chemical Production: Serves as a specialized intermediate in the custom synthesis of high-value, complex organic molecules.

Basic Information

Product Name	D-Proline, 1-Methyl-5-Oxo-
CAS No.	952345-00-5
Molecular Formula	C6H9NO3
Molecular Weight	143.14 g/mol
Synonyms	(2R)-1-Methyl-5-oxopyrrolidine-2-carboxylic acid; D-1-Methyl-5-oxoproline; (R)-1-Methyl-5-oxoproline; D-1-Methylpyroglutamic acid; (R)-1-Methylpyroglutamic acid; D-1-Methyl-5-pyrrolidone-2-carboxylic acid; (2R)-1-Methyl-5-oxo-2-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our D-Proline, 1-Methyl-5-Oxo- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.