Description

4-[4-Methyl-5-(Methylthio)-4H-1,2,4-Triazol-3-Yl]Piperidine, n-Boc Protected CAS NO 952183-43-6 is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core functionalized with a substituted 1,2,4-triazole moiety and protected with a tert-butoxycarbonyl (Boc) group. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities with improved efficacy and safety profiles.
• Protease Inhibitor Synthesis: Serves as a precursor or core structure in the development of protease inhibitors, given the common use of piperidine and triazole motifs in such compounds.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying enzyme function and biological pathways within academic and industrial research settings.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and commercial APIs.
• Library Synthesis for High-Throughput Screening: Used to generate focused libraries of compounds for screening against various biological targets to identify new hits.

Basic Information

Product Name	4-[4-Methyl-5-(Methylthio)-4H-1,2,4-Triazol-3-Yl]Piperidine, n-Boc Protected
CAS No.	952183-43-6
Molecular Formula	C14H24N4O2S
Molecular Weight	312.43 g/mol
Synonyms	1-Boc-4-(4-methyl-5-(methylthio)-4H-1,2,4-triazol-3-yl)piperidine; tert-Butyl 4-(4-methyl-5-(methylthio)-4H-1,2,4-triazol-3-yl)piperidine-1-carboxylate; 4-(4-Methyl-5-methylsulfanyl-4H-[1,2,4]triazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester; N-Boc-4-(4-methyl-5-(methylthio)-1,2,4-triazol-3-yl)piperidine; Boc-Protected 4-(4-Methyl-5-(Methylthio)-1,2,4-Triazol-3-yl)piperidine; 952183-43-6; Boc-4-MTMP
EINECS	Contact for details

Quality Control

Our 4-[4-Methyl-5-(Methylthio)-4H-1,2,4-Triazol-3-Yl]Piperidine, n-Boc Protected is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.