Description

D-Proline CAS NO 344-25-2 is the D-enantiomer of the non-essential amino acid proline, a key chiral building block and resolving agent in organic synthesis. This high-purity enantiomer is critical for applications requiring specific stereochemistry, such as the development of pharmaceuticals and bioactive peptides. It serves as an essential raw material for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and metabolic disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-configuration into peptide chains, modifying their biological activity, stability, and resistance to enzymatic degradation.
• Chiral Resolution Agent: Employed as a resolving agent to separate racemic mixtures of other compounds due to its specific stereochemistry.
• Biochemical Research: A fundamental reagent in enzymology and molecular biology studies to investigate enzyme specificity, protein structure, and metabolic pathways.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for stereoselective chemical reactions.
• Nutraceutical & Cosmetic Formulations: Used in advanced research for specialized cosmetic actives and nutraceutical products where specific stereoisomers are required for efficacy.

Basic Information

Product Name	D-Proline
CAS No.	344-25-2
Molecular Formula	C5H9NO2
Molecular Weight	115.13 g/mol
Synonyms	(R)-(-)-Proline; (R)-Pyrrolidine-2-carboxylic acid; D-(-)-Proline; (2R)-Pyrrolidine-2-carboxylic acid; (-)-Proline; D-Pyrrolidine-2-carboxylic acid; (R)-2-Pyrrolidinecarboxylic acid
EINECS	206-452-3

Quality Control

Our D-Proline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling, to meet the stringent requirements of research and cGMP manufacturing. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Optical Rotation [α]20/D	-80° to -86° (c=1 in H2O)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.