Description

n-Benzyloxycarbonyl-L-Proline is a protected amino acid derivative widely used as a key chiral building block in organic synthesis. This compound is essential for the controlled elongation of peptide chains, particularly in the synthesis of complex, biologically active molecules. It is a critical raw material for research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity intermediates for peptide and peptidomimetic drug development.

Application

• Peptide Synthesis: Serves as a crucial N-protected proline derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) containing proline motifs.
• Bioconjugation & Linker Chemistry: Acts as a starting material for constructing specialized linkers and protecting groups in bioconjugation strategies.
• Catalyst & Ligand Preparation: Employed in the synthesis of chiral catalysts and ligands for asymmetric synthesis.
• Academic & Industrial R&D: A fundamental reagent for exploring new synthetic methodologies and novel compound libraries in medicinal chemistry.
• Custom Synthesis: Provides a versatile scaffold for the custom synthesis of complex organic molecules and proprietary compounds.

Basic Information

Product Name	n-Benzyloxycarbonyl-L-Proline
CAS No.	1148-11-4
Molecular Formula	C₁₃H₁₅NO₄
Molecular Weight	249.26 g/mol
Synonyms	Z-L-Proline; N-Cbz-L-Proline; (S)-1-((Benzyloxy)carbonyl)pyrrolidine-2-carboxylic acid; L-Proline, N-[(phenylmethoxy)carbonyl]-; Cbz-L-Proline; N-Carbobenzoxy-L-proline; NSC 3349; N-Benzyloxycarbonyl-L-proline; N-α-Carbobenzoxy-L-proline
EINECS	214-556-9

Quality Control

Our n-Benzyloxycarbonyl-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and supply chain reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-55.0° to -60.0° (c=1 in Acetic Acid)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.