Description

Cyclohexaneacetic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-1-Methyl-, (αs)- is a high-purity, advanced pharmaceutical intermediate featuring a unique chiral center and a protected amino acid backbone. This compound matters for its critical role in the synthesis of complex, biologically active molecules, offering researchers and manufacturers a reliable building block for constructing sophisticated peptide mimetics and drug candidates. It is primarily needed by pharmaceutical R&D teams and fine chemical producers engaged in developing new therapeutic agents, particularly in the fields of oncology, metabolic disorders, and neurology.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Peptidomimetic Synthesis: Used to incorporate constrained cyclohexylalanine analogs into peptide chains to enhance metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various enzymatic targets.
• Chemical Biology Research: Employed in the study of protein-protein interactions and as a tool compound in medicinal chemistry programs.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Utilized in university laboratories for methodological development in asymmetric synthesis and stereoselective reactions.

Basic Information

Product Name	Cyclohexaneacetic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-1-Methyl-, (αs)-
CAS No.	951789-86-9
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	(αS)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-methylcyclohexaneacetic acid; Boc-(α-Me)Cha-OH; tert-Butoxycarbonyl-(α-methyl)cyclohexylalanine; N-Boc-α-methylcyclohexylalanine; (S)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-cyclohexylpropanoic acid; Boc-α-Me-Cha-OH; (S)-N-Boc-2-amino-2-methyl-3-cyclohexylpropanoic acid
EINECS	Contact for details

Quality Control

Our Cyclohexaneacetic Acid, α-[[(1,1-Dimethoxy)Carbonyl]Amino]-1-Methyl-, (αs)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.