Description

Sildenafil-D8 CAS NO 951385-68-5 is a deuterated analog of Sildenafil, a well-known active pharmaceutical ingredient. This stable isotope-labeled compound is an essential tool for quantitative bioanalytical research, offering superior precision and reliability in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug development and analytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the accurate quantification of Sildenafil and its metabolites in biological matrices.
• Pharmacokinetic (PK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Profiling: Used in studies to identify and quantify the metabolic pathways and products of Sildenafil.
• Bioanalytical Method Development and Validation: A key reference material for developing, optimizing, and validating robust analytical methods compliant with FDA and ICH guidelines.
• Doping Control Analysis: Employed in sports anti-doping laboratories for the sensitive and confirmatory detection of Sildenafil misuse.
• Forensic Toxicology: Applied in forensic investigations for the definitive identification and measurement of Sildenafil in casework samples.

Basic Information

Product Name	Sildenafil-D8
CAS No.	951385-68-5
Molecular Formula	C22H22D8N6O4S
Molecular Weight	482.59 g/mol
Synonyms	1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine-d8; Sildenafil (phenyl-d5, piperazine-d3); UK-92480-d8; Deuterated Sildenafil; Sildenafil-d8 Isotope; Viagra-d8 (labeled compound)
EINECS	Contact for details

Quality Control

Our Sildenafil-D8 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant guidelines for reference standards, supporting compliance in GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.