Description

Bis-Bromoacetamido-Peg11 is a heterobifunctional polyethylene glycol (PEG) derivative featuring reactive bromoacetamido groups at both termini. This compound is a critical reagent for the site-specific conjugation and crosslinking of biomolecules, enabling the creation of stable, well-defined bioconjugates. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for applications such as antibody-drug conjugate (ADC) development, protein engineering, and the synthesis of advanced drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a cleavable or non-cleavable bifunctional linker to connect cytotoxic payloads to monoclonal antibodies.
• Protein & Peptide PEGylation: Enables the site-specific modification of proteins and peptides to enhance solubility, stability, and pharmacokinetic profiles.
• Biomolecule Crosslinking: Used to crosslink proteins, oligonucleotides, or other molecules for structural studies, assay development, or creating multi-valent constructs.
• Surface Functionalization: Facilitates the covalent attachment of biomolecules to nanoparticles, biosensors, and other solid supports for diagnostic and therapeutic platforms.
• Polymer-Protein Conjugate Synthesis: A key intermediate in the synthesis of advanced polymer therapeutics and drug delivery vehicles.
• Hydrogel Formation: Can be used as a crosslinker in the formation of PEG-based hydrogels for tissue engineering and controlled release applications.

Basic Information

Product Name	Bis-Bromoacetamido-Peg11
CAS No.	951308-86-4
Molecular Formula	C31H60Br2N2O14
Molecular Weight	844.63 g/mol
Synonyms	α,ω-Bis(bromoacetamido) PEG11; Bis-Bromoacetamide-PEG11; 1,1'-[11,14-Dioxo-3,6,9,12,15,18,21,24,27,30,33-undecaoxa-10,13-diazapentatriacontane-1,35-diyl]bis(2-bromoethanone); PEG11 bis(bromoacetamide); BrAc-NH-PEG11-NH-BrAc; Heterobifunctional PEG Bromoacetamide; Bromoacetyl-PEG11-Bromoacetamide
EINECS	Contact for details

Quality Control

Our Bis-Bromoacetamido-Peg11 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical research and development. Comprehensive Certificates of Analysis (COA) detailing purity, molecular weight distribution, and residual solvent levels are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Average Molecular Weight	~844 g/mol
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.