Description

tert-Butyl (1-Ethynylcyclohexyl)Carbamate is a specialized carbamate-protected alkyne building block of significant interest in advanced organic synthesis. This compound matters for its unique bifunctional structure, combining a robust tert-butyloxycarbonyl (Boc) protecting group with a reactive terminal alkyne moiety on a cyclohexyl scaffold, enabling precise molecular construction. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as click chemistry, Sonogashira cross-couplings, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS research.
• Click Chemistry Reagent: Utilized in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer modification, and material science applications.
• Cross-Coupling Substrate: Serves as a critical coupling partner in palladium-catalyzed Sonogashira reactions to form conjugated enynes and complex molecular architectures.
• Agrochemical Synthesis: Employed in the research and development of new herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Used in the development of advanced polymers, dendrimers, and functionalized surfaces requiring alkyne handles.
• Academic & R&D: A valuable tool for methodological development in organic chemistry and exploring new synthetic pathways in university and industrial laboratories.

Basic Information

Product Name	tert-Butyl (1-Ethynylcyclohexyl)Carbamate
CAS No.	950522-83-5
Molecular Formula	C₁₃H₂₁NO₂
Molecular Weight	223.31 g/mol
Synonyms	Boc-1-Ethynylcyclohexylamine; 1-Ethynylcyclohexyl Carbamic Acid tert-Butyl Ester; N-Boc-1-Ethynylcyclohexanamine; N-(tert-Butoxycarbonyl)-1-ethynylcyclohexanamine; tert-Butyl N-(1-ethynylcyclohexyl)carbamate; 1-(tert-Butoxycarbonylamino)-1-ethynylcyclohexane; (1-Ethynylcyclohexyl)carbamic Acid 1,1-Dimethylethyl Ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (1-Ethynylcyclohexyl)Carbamate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.