Description

1-Iodo-2-(Trimethylsilyl)Acetylene 97 is a versatile organosilicon reagent featuring both a terminal alkyne and an iodine substituent, protected by a trimethylsilyl (TMS) group. This compound is a crucial building block in advanced organic synthesis, enabling efficient carbon-carbon bond formation and serving as a precursor to complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing novel compounds and functional materials.

Application

• Sonogashira Coupling Reactions: A key reagent for palladium-catalyzed cross-coupling with aryl or vinyl halides to form conjugated enynes or arylalkynes.
• Synthesis of Functionalized Alkynes: Serves as a protected alkyne synthon; the TMS group can be selectively removed to reveal a terminal alkyne for further derivatization.
• Pharmaceutical Intermediate: Used in the construction of active pharmaceutical ingredients (APIs) and complex natural product analogs that require alkyne functionality.
• Material Science & Polymer Chemistry: Building block for creating conjugated polymers, dendrimers, and organic electronic materials with specific optoelectronic properties.
• Agrochemical Research: Intermediate in the synthesis of novel herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Precursor for synthesizing specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Iodo-2-(Trimethylsilyl)Acetylene 97
CAS No.	18163-47-8
Molecular Formula	C5H9ISi
Molecular Weight	224.11 g/mol
Synonyms	(Iodoethynyl)trimethylsilane; Trimethyl((iodoethynyl))silane; (Trimethylsilyl)iodoacetylene; TMS-Iodoacetylene; Ethynyltrimethylsilane, iodo-; 1-Iodo-2-trimethylsilylacetylene; Iodotrimethylsilylacetylene
EINECS	Contact for details

Quality Control

Our 1-Iodo-2-(Trimethylsilyl)Acetylene 97 is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including GC, NMR, and titration methods, to ensure a minimum purity of 97% and conformity to specification. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile and light-sensitive nature, containers should be kept sealed and handled under an inert atmosphere when possible to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Density (at 20°C)	~1.5 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.