Description

Cyclooctyne CAS NO 1781-78-8 is a highly reactive, strained cyclic alkyne that serves as a cornerstone reagent in modern synthetic chemistry. Its unique structure enables rapid, catalyst-free reactions with azides, making it indispensable for advanced bioconjugation and materials science. This compound is critical for researchers and manufacturers in pharmaceutical development, chemical biology, and polymer science who require efficient, bioorthogonal ligation strategies.

Application

• Bioorthogonal Chemistry: A key component in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions for labeling biomolecules in living systems without interfering with native biochemical processes.
• Pharmaceutical Research: Used for the site-specific conjugation of drugs, antibodies, and imaging agents to create targeted therapeutics and diagnostics.
• Materials Science: Enables surface functionalization and the creation of novel polymer networks and smart materials via click chemistry.
• Chemical Biology: Facilitates the study of biomolecular interactions and cellular processes through the labeling of proteins, glycans, and lipids.
• Agrochemical Development: Employed in the synthesis of novel active ingredients and formulation adjuvants with specific targeting properties.
• Academic & Industrial R&D: Serves as a fundamental building block for synthesizing complex molecular architectures and exploring new reaction pathways.

Basic Information

Product Name	Cyclooctyne
CAS No.	1781-78-8
Molecular Formula	C8H12
Molecular Weight	108.18 g/mol
Synonyms	1,2-Cyclooctadiene; Cycloocta-1,2-diene; 1,2-Cyclooctadiene (cyclic alkyne form); Bicyclo[6.1.0]non-1(8)-ene; SPAAC reagent; Cyclic C8 alkyne; Octahydrobenzene (not recommended); 1-Cyclooctyne
EINECS	217-228-4

Quality Control

Our Cyclooctyne is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot is characterized by comprehensive analytical techniques including NMR, GC-MS, and HPLC to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and easily oxidized nature, this material should be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C. Keep the container tightly sealed in a cool, dry, and well-ventilated place away from heat and ignition sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.