Description

(S,S)-(4,5-Dihydro-4-Isopropyl-2-Oxazolyl)-2-[Di(1- Naphthyl)Phosphino]Ferrocene is a highly specialized, chiral ferrocenyl phosphine-oxazoline ligand, a cornerstone in advanced asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and catalytic activity in a range of transition metal-catalyzed reactions, enabling the synthesis of complex, single-enantiomer molecules. This ligand is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for creating high-value intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, critical for producing chiral alcohols and amines in pharmaceutical synthesis.
• Asymmetric C-C Bond Formation: Employed in reactions such as allylic alkylation, conjugate addition, and cross-coupling to construct chiral carbon frameworks with high fidelity.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of single-enantiomer drug candidates and active pharmaceutical ingredients (APIs) for therapeutic areas including oncology and CNS disorders.
• Agrochemical Product Development: Used in the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is often enantiomer-specific.
• Fine Chemical and Flavor/Fragrance Manufacturing: Enables the asymmetric synthesis of complex aroma chemicals and specialty fine chemicals with defined stereochemistry.
• Academic and Industrial R&D: A vital tool for methodology development in academic laboratories and for scaling up novel catalytic processes in industrial settings.

Basic Information

Product Name	(S,S)-(4,5-Dihydro-4-Isopropyl-2-Oxazolyl)-2-[Di(1- Naphthyl)Phosphino]Ferrocene
CAS No.	950201-43-1
Molecular Formula	C36H32FeNOP
Molecular Weight	557.47 g/mol
Synonyms	(S,S)-iPr-FOXAP; (S,S)-4,5-Dihydro-4-(1-methylethyl)-2-[2-[bis(1-naphthalenyl)phosphino]ferrocenyl]-2-oxazole; (S,S)-2-[Bis(1-naphthyl)phosphino]-1-[(4-isopropyl-4,5-dihydrooxazol-2-yl)]ferrocene; (S,S)-FOXAP Ligand; (S,S)-Ferrocenyloxazolinylphosphine Ligand; Josiphos-type ligand variant; Chiral ferrocenyl phosphine-oxazoline ligand
EINECS	Contact for details

Quality Control

Every batch of our (S,S)-(4,5-Dihydro-4-Isopropyl-2-Oxazolyl)-2-[Di(1- Naphthyl)Phosphino]Ferrocene is synthesized and purified under stringent conditions to ensure high chiral purity and catalytic performance. Quality is verified through a comprehensive suite of analytical techniques including NMR, HPLC, and elemental analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess. Our quality management system supports traceability and consistency for cGMP and research-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light may degrade performance. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.