Description

Fmoc-D-Ala(1-Pyrazolyl)-Oh is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis. This compound matters for its role as a critical building block in the development of novel peptide-based pharmaceuticals and research tools, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in solid-phase peptide synthesis (SPPS), particularly for creating peptides with enhanced stability, bioavailability, or specific biological activity. Its unique structure incorporating the 1-pyrazolyl side chain makes it valuable for medicinal chemistry and drug discovery programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides.
• Medicinal Chemistry & Drug Discovery: Used to incorporate non-natural amino acids into peptide leads to modulate pharmacokinetic properties and receptor binding.
• Bioconjugation: Serves as a functionalized linker for attaching peptides to other molecules, surfaces, or biomolecules.
• Pharmaceutical Intermediate: A critical raw material in the research and development stages of therapeutic peptides.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by creating tailored peptide probes.
• Peptidomimetic Development: Used to create peptide analogs that mimic natural peptides but with improved metabolic stability.

Basic Information

Product Name	Fmoc-D-Ala(1-Pyrazolyl)-Oh
CAS No.	948594-98-7
Molecular Formula	C22H21N3O4
Molecular Weight	391.42 g/mol
Synonyms	Fmoc-D-3-(1H-Pyrazol-1-yl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(1H-pyrazol-1-yl)-D-alanine; Fmoc-D-Ala(1-Pyz)-OH; Fmoc-D-β-(1-pyrazolyl)alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-pyrazol-1-yl)propanoic acid; Nα-Fmoc-D-3-(1-pyrazolyl)alanine; Fmoc-D-1-pyrazolylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Ala(1-Pyrazolyl)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with research or cGMP starting material requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.