Description

Cixutumumab CAS NO 947687-12-9 is a fully human monoclonal antibody targeting the insulin-like growth factor-1 receptor (IGF-1R). This compound is of significant interest for its potential to inhibit tumor cell proliferation and survival pathways. It is primarily utilized in advanced pharmaceutical research and development, particularly in the field of oncology therapeutics.

Application

• Oncology Research: Investigational agent for studying IGF-1R signaling pathways in various cancer models.
• Preclinical Development: Used in the development and evaluation of novel anti-cancer biologics and combination therapies.
• Biopharmaceutical Manufacturing: Serves as a reference standard or key intermediate in the production of therapeutic antibodies.
• Mechanistic Studies: Tool for understanding resistance mechanisms to targeted cancer therapies.
• Diagnostic Reagent Development: Potential use in the development of companion diagnostics for personalized medicine.

Basic Information

Product Name	Cixutumumab
CAS No.	947687-12-9
Molecular Formula	C6450H9936N1720O2016S46
Molecular Weight	~145 kDa
Synonyms	IMC-A12; Anti-IGF-1R Recombinant Monoclonal Antibody; Human Anti-IGF1R IgG1, lambda; IGF-1R Inhibitor IMC-A12; LY3012217; NSC-742460; Therapeutic Monoclonal Antibody A12
EINECS	Contact for details

Quality Control

Our Cixutumumab is produced and tested under stringent conditions to ensure the highest standards of purity and biological activity, suitable for research and development purposes. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, potency, and sterility. We adhere to relevant quality guidelines to support our global clientele in pharmaceutical and biotech applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (SDS-PAGE)	Corresponds to reference standard
Purity (SEC-HPLC)	≥ 95% (Monomer)
Protein Content (UV)	Contact for details
Biological Activity (Binding ELISA)	Contact for details
Endotoxin (LAL)	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.